I would first recommend to ensure you’re on the latest available device firmware. If your AV.io has an outdated firmware it’s possible this could be the cause. You will need to download and install the configuration tool to update the firmware. Both the firmware and the config tool can be found on the device support page.
https://www.epiphan.com/support/avio-4k-software-documentation/?utm_source=Support&utm_medium=Web&utm_campaign=avio-4k
If the issue persists after the firmware update, it’s possible it could be a compatibility issue with the active adapter and I would recommend testing a different make/model